Study: CBD Administration Reduces Blood Pressure

oil_bottlesOral CBD administration is associated with reduced blood pressure in healthy volunteers, according to clinical trial data published online in the Journal of Clinical Investigation.

Investigators from the University of Nottingham in the United Kingdom assessed the effects of a single oral dose of 600 mg of CBD extract versus placebo in nine male subjects.

Cannabidiol administration reduced resting systolic blood pressure and stroke volume (the amount of blood pumped by the left ventricle of the heart in one contraction). Compared to placebo, CBD intake was associated with reduced BP levels following exercise and in response to stress. Increased heart rate was observed following CBD administration, but no “adverse events” were reported by participants either during or following the study sessions.

Authors concluded: “Our data show that a single dose of CBD reduces resting blood pressure and the blood pressure response to stress, particularly cold stress, and especially in the post-test periods. This may reflect the anxiolytic and analgesic effects of CBD, as well as any potential direct cardiovascular effects. … Further research is also required to establish whether CBD has any role in the treatment of cardiovascular disorders such as a hypertension.”

Full text of the study, “A single dose of cannabisiol reduces blood pressure in healthy volunteers in a randomized crossover study,” is online here.

Low-dose THC can relieve stress; more does just the opposite

Low levels tetrahydrocannabinol, or THC, the main psychoactive compound in marijuana, does reduce stress, but in a highly dose-dependent manner, new research confirms.

Natural chemical helps brain adapt to stress

A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience — the ability to adapt to repeated and acute exposures to traumatic stress.

How the federal government limits valid scientific research on Cannabis sativa

The use of medical marijuana for millions of patients suffering from a wide range of health conditions and the subsequent therapeutic benefits has long been documented. Cannabis sativa can benefit patients suffering from a wide range of conditions, including cancer, epilepsy, chronic pain, and post-traumatic stress disorder. So given all the health benefits for people experiencing debilitating health issues, why does the federal government continue to stifle valid, externally valid scientific research on Cannabis sativa?

How the brain suppresses pain during times of stress

How does the brain suppress pain? For the first time, it has been shown that suppression of pain during times of fear involves complex interplay between marijuana-like chemicals and other neurotransmitters in a brain region called the amygdala.

San Jose Medical Marijuana 420 Evaluations Now Open to Help Patients Achieve Natural and Affordable Pain Relief


San Jose, CA (Vocus/PRWEB) March 07, 2011

Patients in need often struggle to find reasonably priced medication for their worst aches and pains. The mission of newly opened San Jose 420 Evaluations is to provide Bay Area residents with affordable medical marijuana recommendations, and a superior solution to their chronic condition. Getting a medical marijuana card has never been easier because San Jose 420 Evaluations provides care to anyone in need.

?Money should not interfere or prevent people from getting the recommendation they need,? said Eugene, who founded San Jose 420 Evaluations in July 2010. ?I always give discounts to Veterans and anyone else in need.?

At San Jose 420 Evaluations, a licensed physician personally reviews each case, ensuring patient?s security and comfort. Common ailments that warrant a doctor?s recommendation for medical cannabis include cancer, AIDS, anorexia, chronic pain, spasticity, glaucoma, arthritis, migraine, insomnia, PMS, post-traumatic stress disorder (PTSD), depression, and substance abuse.

San Jose medical card carriers gain access to legal marijuana from a variety of dispensaries, all specializing in the holistic healing of pain. Under California State Law, a patient must have a physician recommendation to obtain a Medical Marijuana Card for access to Medicinal Marijuana. Medical Marijuana Recommendations are valid for one year.

To consult with a San Jose medical marijuana doctor and obtain a medical marijuana card, make an appointment with San Jose 420 Evaluations at (408) 916-1407. Walk-ins are welcome, so visit their practice at 115 North 4th Street, #106, San Jose CA 95112. San Jose 420 Evaluations can also be found online at http://www.sanjoseevaluations.com.

About San Jose 420 Evaluations:

San Jose 420 Evaluations is a Medical Cannabis clinic in San Jose and serving all of the South Bay. San Jose 420 provides efficient, and compassionate medical evaluations for those qualified to access Medical Marijuana. San Jose 420 is a physician owned and operated clinic offering evaluations given only by California MD?s.

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Related Medical Marijuana Doctors Press Releases

Grow Tip: Shall I Cut Or Let Them Stay II?

Several people commented on my Grow Tip #46? Shall I Cut Or Let Them Stay? I advised the grower to consider harvesting early when facing cool, inclement or moist weather.

Cory Moe said to cover them with a piece of plastic.

Pot Smoker advised to shake the water off in the morning.

Hubert Savage wrote about building a temporary greenhouse.

I disagree. None of these solutions deals with the real problems: high humidity and cool temperature. These conditions stop plant growth and promote the growth of botrytis, the cause of brown or grey mold. Unless you can lower the humidity and raise the temperature, the plants will be susceptible to attack.

The various preventatives, both chemical and biological, will not be able to protect 100% against disease organisms under severe environmental stress. Although the thought of having to harvest early is a disappointment, the reality of rotting buds is even more depressing.

Study: Cannabis May Mitigate Traumatic Memories In Patients With PTSD

[Editor's note: This post is excerpted from this week's forthcoming NORML weekly media advisory. To have NORML's news alerts and legislative advisories delivered straight to your in-box, sign up here.]

The use of cannabis and cannabinoids appears to mitigate symptoms associated with post-traumatic stress disorder (PTSD), according to a new review of clinical and preclinical evidence published online in the scientific journal Drug Testing and Analysis.

An international team of investigators from Germany, the United States, and the United Kingdom reported that the use of cannabis to “dramatically reduced” PTSD symptoms in a single 19-year-old male patient.

Authors reported: “In the case report presented in this review, the patient displayed a grave pathology involving anxiety, dissociation and heavy flashbacks as a consequence of PTSD. … The patient stated that he found cannabis more useful than lorazepam. … It is evident from the case history that the patient experienced reduced stress, less involvement with flashbacks and a significant decrease of anxiety.

Authors further cited “accumulating clinical and preclinical evidence that cannabinoids may mitigate some major symptoms associated with PTSD.”

They concluded: “Cannabis may dampen the strength or emotional impact of traumatic memories through synergistic mechanisms that might make it easier for people with PTSD to rest or sleep and to feel less anxious and less involved with flashback memories. … Evidence is increasingly accumulating that cannabinoids might play a role in fear extinction and anti-depressive effects. It is concluded that further studies are warranted in order to evaluate the therapeutic potential of cannabinoids in PTSD.”

Last year, administrators at the United States Department of Health and Human Services, National Institute on Drug Abuse (NIDA) blocked investigators at the University of Arizona at Phoenix from conducting an FDA-approved, placebo-controlled clinical trial to evaluate the use of cannabis in 50 patients with PTSD.

Under federal law, any clinical trial evaluations involving cannabis must receive NIDA approval because the agency is the only source of legal cannabis for FDA-approved research purposes. In 2010, a spokesperson for the agency told The New York Times: “[O]ur focus is primarily on the negative consequences of marijuana use. We generally do not fund research focused on the potential beneficial medical effects of marijuana.”

Anticonvulsant drug helps marijuana smokers kick the habit

Scientists have found clinical evidence that the drug gabapentin, currently on the market to treat neuropathic pain and epilepsy, helps people to quit smoking marijuana (cannabis). Unlike traditional addiction treatments, gabapentin targets stress systems in the brain that are activated by drug withdrawal.

Military weed? Unacceptable. Military speed? Encouraged!

When you read a story like this, it makes it even more infuriating that our government fights to keep cannabis out of the hands of our vets with PTSD…

(LA Times) SEATTLE — U.S. Air Force pilot Patrick Burke‘s day started in the cockpit of a B-1 bomber near the Persian Gulf and proceeded across nine time zones as he ferried the aircraft home to South Dakota.

Every four hours during the 19-hour flight, Burke swallowed a tablet of Dexedrine, the prescribed amphetamine known as “go pills.” After landing, he went out for dinner and drinks with a fellow crewman. They were driving back to Ellsworth Air Force Base when Burke began striking his friend in the head.

“Jack Bauer told me this was going to happen — you guys are trying to kidnap me!” he yelled, as if he were a character in the TV show “24.”

After two long-running wars with escalating levels of combat stress, more than 110,000 active-duty Army troops last year were taking prescribed antidepressants, narcotics, sedatives, antipsychotics and anti-anxiety drugs, according to figures recently disclosed to The Times by the U.S. Army surgeon general. Nearly 8% of the active-duty Army is now on sedatives and more than 6% is on antidepressants — an eightfold increase since 2005.

For the Army and the Marines, using the drugs has become a wager that whatever problems occur will be isolated and containable, said James Culp, a former Army paratrooper and now a high-profile military defense lawyer. He recently defended an Army private accused of murder, arguing that his mental illness was exacerbated by the antidepressant Zoloft.

The potential effect on military personnel has special resonance in the wake of several high-profile cases, most notably the one involving Staff Sgt. Robert Bales, accused of murdering 17 civilians in Afghanistan. His attorneys have asked for a list of all medicines the 38-year-old soldier was taking.

Fueling much of the controversy in recent years, though, are reports of a possible link between the popular class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) — drugs such as ProzacPaxil and Zoloft, which boost serotonin levels in the brain — and an elevated risk of suicide among young people. The drugs carry a warning label for those up to 24 — the very age of most young military recruits.

Don’t you just love an anti-depressant that has as a side effect an elevated risk of suicide?  ”Doc, I’m depressed, I want to kill myself.”  Here, have some Prozac!  It should help, unless it makes you want to kill yourself.  What could be the effect of over-prescribing these SSRIs to young people between the ages of 18-24 who are already deep into the most stressful situation possible?

(EdmondSun.com) EDMOND — The United States military has an epidemic of suicide, said retired Maj. Gen. Rita Aragon, secretary of Veterans Affairs for the state of Oklahoma.

The Edmond resident told members of the AMBUCS service club Friday that 10 percent of the 3 million U.S. military personnel either attempt suicide or commit suicide.

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Cannabinoids after a traumatic experience may prevent post-traumatic stress symptoms, rat study suggests

Administration of cannabinoids (in the form of synthetic marijuana) after experiencing a traumatic event blocks the development of post-traumatic stress disorder-like symptoms in rats, according to a rat study conducted by researchers in Israel.

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